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Monday, January 10, 2005

2nd dose worse than the 1st... 

My reaction to Mirapex unfortunately is a familiar one....the same thing has happened with anti-depressants, muscle relaxants, gastroparesis meds, and believe it or not, guaifenisen. I seem to have a particular problem with meds that cross the brain-blood barrier....I believe it all started with brain damage from taking Paxil.

Before I took the first dose of Mirapex, I looked up possible side effects and noted that during clinical trials, the main reasons for discontinuation were increase in dyskinesia, headache, dizziness and nausea, all of which I experienced. I also noted that these did NOT appear to be dose related, and did not go away after a trial period. Also, the handout from the pharmacy listed insomnia as a common side effect.

Because some of the meds I've reacted to have affected me for weeks at a time off a very few doses, if I suspect I could have problems, I will only try two doses before calling a doc to see if I should continue. This is what I did today.....I left a message for the sleep specialist with the nurse. I haven't received a call back, but I will NOT take another Mirapex until I am assured it is safe to do so.

Last night, the second dose seemed even stronger than the first.....it took a few hours to kick in, but when it did, sleep was a lost cause, and all I could do was hang on to the side of the bed and twitch. The nausea was much worse, and if I hadn't been so dizzy, I would have taken a pillow and blanket into the bathroom with me. This of course set off the fibromyalgia so that every fiber of my body ached.

When this has happened before, I've discovered that what I really need to do is mild exercise.....that sounds insane, but if I continue to lie in bed, my muscles will start to cramp up, and the pain then is excructiating and takes days to resolve. So I showed up for my aquacise class even though I felt like death warmed over. I moved a bit cautiously due to the nausea, but I got through successfully, came home and promptly collapsed into bed.

For the rest of the day, I've slept an hour or two, gotten up and stretched a bit, maybe watched a little tv, and then laid back down again. Had to call in sick to work again...that's twice this year already. I think the med finally left my system about two hours ago, because the nausea finally lifted enough for me to eat some solid food.

I get very upset when I react to meds, and often docs and the world at large aren't terribly sympathetic. It is tough to be at the mercy of a pill that was supposed to help you and instead wreaks havoc.

I think I will try to make some gluten-free mac and cheese. I still feel hung over, but a little comfort food ought to help.

Pain level: 9
Fatigue level: 9

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